Patients with HIV-associated lipodystrophy show both impaired insulin-stimulated whole-body oxidative glucose disposal (Behrens et al. 2002) and impaired nonoxidative glucose disposal (van der Valk et al. 2001; Behrens et al. 2002; Andersen et al. 2003; Haugaard et al. 2005) indicating peripheral insulin resistance. This evidence concerns the gene INS and Insulin resistance.