Thus, if inhibiting Mdm2 expression or function in tumor cells is an appealing anti-cancer strategy, we can, however, question what could be the consequence of systemic targeting for striated muscles, including respiratory muscles, diaphragm, skeletal muscles, and cardiac muscle, with an impact on vital functions such as locomotion, blood circulation, respiration, and metabolic homeostasis. This evidence concerns the gene MDM2 and neoplasm.