Also, Mdm2 involvement in promoting tumor angiogenesis and inflammation has recently emerged through its implication in vascular endothelial growth factor-A (VEGF-A) proangiogenic and NF-κB proinflammatory signaling (Nieminen et al. 2005; Carroll and Ashcroft 2008; Busuttil et al. 2010; Thomasova et al. 2012). This evidence concerns the gene MDM2 and neoplasm.