Galectin-3 upregulates β-catenin expression, increases its nuclear accumulation, and augments Wnt/β-catenin signaling in human colon cancer cells by regulating glycogen synthase kinase-3β (GSK-3β) phosphorylation and activity via the PI3K/Akt pathway [19]. The gene discussed is LGALS3; the disease is malignant colon neoplasm.