Similar down-regulation of miR-381 and miR-495 was also observed in the other MDR cell line, K562/VBL, which also expressed MDR1/P-gp at high levels similar to K562/ADM (Figure 3D; Figure S1), suggesting a common phenomenon in MDR leukemia cells in which MDR1 gene expression is negatively correlated with miR-381 and/or miR-495 expression levels. This evidence concerns the gene ABCB1 and leukemia.