The data show that combination BMSC and Niaspan treatment of stroke in T1DM initiated at 24h after MCAo did not decrease brain hemorrhage transformation (Figure 2A), but decreased BBB leakage compared with BMSC monotherapy in T1DM animals (Figure 2B) identified by albumin staining (p<0.05). The gene discussed is ALB; the disease is intracranial hemorrhage.