However, Niaspan and combination of BMSC+Niaspan treatment significantly attenuated BMSC induced Angiogenin, MMP9 and ED1 expression in the ischemic brain and in the ICA compared to T1DM-MCAo control and BMSC monotherapy treatment group (p<0.05 vs. T1DM-MCAo control; p<0.05 vs. BMSC monotherapy treatment group). This evidence concerns the gene EDA and type 1 diabetes mellitus.