There is a complicated interaction between the two diseases mediated by inflammatory cytokines among others.[101] Numerous DEG-coded proteins associated with both diseases could be found in central proteins like PPARG, INS-IGF2, LEP etc.[102]–[104] Others, like PIK3R1, AR and MEF2A may have role in the development of metabolic syndrome in psoriasis. This evidence concerns the gene PIK3R1 and metabolic syndrome.