IRF1 and psoriasis: Many proteins published in association with the immunopathogenesis of psoriasis were highly ranked hubs in PPI networks: IL1, IL8, TGFB1, SP1, STAT1, STAT3, NFKB1, IRF1 etc.[87], [91]–[97] A highly interconnected cluster mainly consisting of upregulated chemokines and chemokine receptors was also found by PPI analysis (Figure S3).