Blood glucose-lowering drugs act through PPARG and INS-IGF2 activation, which can be the basis of the positive effects of fibrate and HMG-CoA inhibitors in psoriasis as well.[47] Cardiac stimulants such as adrenergic agents also have high impact on lesional skin's PPI and PDI network, mainly by modulating hubs in controller sub-network. The gene discussed is IGF2; the disease is psoriasis.