LZTS2 and neoplasm: In rat cells, the pluripotent tumor suppressor LAPSER1/LZTS2 binds the katanin p80 subunit directly and shares centrosomal and midbody localization with the p80 subunit, and LAPSER1 has been shown to inhibit the microtubule-severing activity of katanin by binding to the p80 subunit [28,29].