BECN1 and intrahepatic cholangiocarcinoma: Interestingly, our stratified survival analysis found that ICC with Beclin 1 low expression was correlated to a worsened OS and PFS than ECC subtype patients, especially than the Beclin 1 highly expressed ECC patients (Figure 4), suggesting that Beclin 1 might be a promising biomarker to select particular patients with high risk to death and disease progression in the subtypes of ICC and ECC.