HRAS and neoplasm: To further test the influence of the normal cell-of-origin on the associated tumor phenotype, we created transformed derivatives of the hTERT immortalized FNE and OCE cells by the sequential introduction of SV40 Large T/small t (SV40T/t) antigen and H-Ras as we described before [2], [43]; these tumorigenic cells are hereafter referred to as FNLER and OCLER, respectively.