In previous studies fallopian tube epithelium has been cultured using different standard media conditions and using similar genetic alterations (including hTERT, SV40T/t and HRAS +/– C-MYC); intriguingly, differences in the resulting tumor histopathology have been reported - two of these studies claimed that the histology of xenograft tumors was consistent with human poorly differentiated serous tumors [17], [50] while the third study observed a poorly differentiated mucinous histology [16]. This evidence concerns the gene HRAS and neoplasm.