The constitutive activation of the TNF-TNFR1-TRAF2 cascade, rather than the RANKL-RANK-TRAF6 or IL-1β-IL1R-IRAK cascades, has been previously reported to underlie IKK stabilization and constitutive NFκB activation in HNSCC cells [10]. This evidence concerns the gene TRAF6 and head and neck squamous cell carcinoma.