Genes presented in 40 and 80 days lists are mostly related to major histocompatibility complex (MHC) class I (H2-Bl, H2-K1, H2-Q1, H2-Q10, H2-Q2, H2-Q7, H2-T22, H2-T23—80 days ALS mice), molecules necessary for peptide loading (Tap2—80 days ALS mice) and to surface expression (B2m—40 days ALS mice) (Kimura and Griffin, 2000). This evidence concerns the gene TAP2 and amyotrophic lateral sclerosis.