Of substantial interest, we might point out the up regulation of Cldn11 at 40 days and the down regulation of Cldn10 at 80 days pre-symptomatic ALS mice, in agreement to previous description on differential regulation of tight junction genes related to specific characteristics of ALS clinical evolution (Henkel et al., 2009). The gene discussed is CLDN10; the disease is amyotrophic lateral sclerosis.