Profound damage to the endothelium occurs during dengue episodes, this is mediated by self-reacting antibodies [31], by cytokines such as TNF-α [32–34] and IFN-γ [35], by other biochemical substances as nitric oxide [36], by apoptotic processes [37], and by the plausible cell destruction mediated by the complement cascade or cytotoxic events. Here, TNF is linked to dengue disease.