EP400 and cancer: We further tested whether Tip60-p400 interacts with Hdac6 in cancer cells, by transfecting epitope-tagged Tip60 and Hdac6 constructs into 293.T cells (to facilitate immunoprecipitation), and found that Tip60 co-precipitated with Hdac6 (Figure 2G), suggesting that, as with ESCs and NSCs, Hdac6 functions within Tip60-p400 complex in some cancer cells.