HDAC6 and cancer: Interestingly, loss-of-function of either Hdac6 or genes encoding Tip60-p400 subunits within cancer cell lines has previously been shown to elicit defects in anchorage-independent growth and hypersensitivity to DNA damaging agents (Feng et al., 2003; Lee et al., 2008; Wang et al., 2012), supporting this hypothesis.