Consistent with the phenotypes shared by Hdac6 KD and Tip60 KD ESCs, both Hdac6 KD and loss-of-function mutations of Tip60-p400 subunits were previously shown to impair anchorage-independent growth and increase DNA damage sensitivity in cancer cells (Feng et al., 2003; Lee et al., 2008; Wang et al., 2012). Here, EP400 is linked to cancer.