EP400 and cancer: Subsequent analyses revealed that Hdac6 also interacts with Tip60-p400 in adult neural stem cells from the brain and some cancer cell lines, but is sequestered away from Tip60-p400 in the cytoplasm of most differentiated cell types, as previously reported (Verdel et al., 2000; Hubbert et al., 2002; Kawaguchi et al., 2003; Valenzuela-Fernández et al., 2008).