We found the most variant (but not necessarily compound heterozygotes) AML-associated genes in infants with AML were TTN, MLL3 and FLG (Figure 2b, columns 1,3,4; Infants: AML), but from the ALL-associated gene list, MDN1, SYNE1 and MLL2 (Figure 2a, columns 1,2,3; Infants: AML) were frequently variable. This evidence concerns the gene FLG and acute myeloid leukemia.