In this molecule, the tyrosinase activated melanoma prodrugs (4-methoxyphenol and N-acetyl-4-S-cysteaminylphenol) were linked to GSH by an ethoxycarbonyl moiety, and the Cys sulfhydryl group was oxidized to sulfone to give compounds 12 and 13 (Figure 6). The gene discussed is TYR; the disease is melanoma.