The tumour necrosis factor-α (TNF-α) inducing drug DMXAA (Vadimezan, ASA404) has been investigated by DCE-MRI in the rat GH3 prolactinoma [144], in a range of murine tumours including MCA205 (methylcholantrene-induced fibrosarcoma) [139] and SaF sarcoma [143], and in a number of human xenografts in mice including HT29 and LS174T colon adenocarcinomas [113], FaDu [137,141,142], A253 [137], and patient-derived [142] head and neck carcinomas. The gene discussed is TNF; the disease is colon adenocarcinoma.