Prindopril, is a tert-butylamine salt of 1-{(2S)-2-[(1S)-1-carbethoxybutyl)amino]-1-oxopropyl}-(2S,3As,7As)-perhydroindole-2-carboxilic acid, belongs to the class of antihypertensive drugs, a long acting angiotensin-converting enzyme (ACE) inhibitor, which is impressive in the treatment and prevention of various medical conditions such as med of mild-to-moderate hypertension [19], congestive heart failure, diabetic nephropathy and post-myocardial infarction [20–23]. This evidence concerns the gene ACE and diabetic kidney disease.