Postoperative liver dysfunction has been defined by the “50-50 criteria” as a prothrombin index of less than 50% (mean normal prothrombin time (PT) divided by patient's observed PT) and a serum bilirubin of >50 μmol/L on the fifth postoperative day, which has been shown to predict liver failure and death after hepatectomy [2]. Here, F2 is linked to liver failure.