There is experimental evidence that demonstrates calpain 1/2 has several roles in cancer progression such as cleaving focal adhesion kinase (FAK) to dynamically regulate integrin-mediated focal adhesion for cell migration (29,30), regulating activation of membrane-type matrix metalloproteinase 1 (MT1-MMP or MMP-14) and matrix metalloproteinase 2 (MMP2) for extra-cellular matrix remodeling and angiogenesis (31), and cancer invasion and metastasis (32,33). Here, MMP2 is linked to cancer.