Numerous drugs have been found to exert a protective effect against LPS-induced ALI, including matrine, which inhibits the inflammatory response (17), heme oxygenase-1, which negatively regulates the interleukin (IL)-33 and Toll-like receptor (TLR)-4-mediated inflammatory response (18), and resolvin D1 which selectively reacts with a lipoxin A4 receptor, inhibiting mitogen-activated protein kinases and the nuclear factor-κ B pathway (19). The gene discussed is HMOX1; the disease is acute respiratory distress syndrome.