In our multivariate analysis, TnT proved to be independently associated with fluid overload, but no correlation was observed between TnT and NT-proBNP as well as documented coronary artery disease, which points toward cardiac damage potentially being caused directly by fluid overload and questions the applicability of TnT in the diagnosis of coronary events in hemodialysis patients. The gene discussed is NPPB; the disease is coronary artery disorder.