The CHIT-1 activity in the control CSF ranged between 0.0169 – 0.1856 μmol/min/μl (Mean: 0.02459 ± 0.01499; n = 13) whereas in the ALS-CSF it was 0.0809 – 4.1658 μmol/min/μl (Mean: 0.9932 ± 0.3023; n = 16). The gene discussed is CHIT1; the disease is amyotrophic lateral sclerosis.