In this study, there was an increase in the levels of uPA and MMP-3 in the endometrium of women with endometriosis, which can facilitate the adhesion of endometriosis tissue in the peritoneum and the surface of the ovary, and the penetration of the extracellular matrix, with the last one resulting in the formation of early endometriosis foci. Here, PLAU is linked to endometriosis.