In this study, there was a significant increase in the peritoneal fluid of women with endometriosis, the levels of vascular endothelial growth factor (Vascular Endothelial Growth Factor-VEGF), the urokinase-type plasminogen activator (urokinase-type Plasminogen Activator-uPA) and the levels of MMP-3 in comparison with women-witnesses without endometriosis. This evidence concerns the gene PLAU and endometriosis.