Expression of EGFR and other erbB receptors are deregulated in many cancers [31] and a study on head and neck squamous cell carcinoma cell lines showed that activation of EGFR leads to increase in chemoresistant fraction of SP cells thereby playing a role in regulating cancer stem cells and tumorigenesis in such tumors [32]. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.