In effect, PARPi are the magic bullets, but instead of doing precision targeting with them for the desired effect, we are simply nuking the entire spectrum of functions of that target PARP, which could result in unintended consequence during maintenance (prolonged) therapy with PARPi including survival of damaged cancer cells, development of secondary tumors as a consequence of genomic instability and resistance to PARPi. The gene discussed is PARP1; the disease is cancer.