(iv) Angiogenesis: the role of PARP-1 in promoting angiogenesis that fuels the growth of tumors can also be target of PARPi, because PARP-1 depletion or PARPi reduce vessel formation (29) and expression of markers of angiogenesis in melanoma (30) or endothelial cells (31). Here, PARP1 is linked to melanoma.