From the perspective of human disease it is most notable that K-Ras is mutated at high prevalence in particular forms of cancer, notably pancreatic, lung, and colon carcinomas, while mutated N-Ras is found at high rates in melanomas and some leukemias, and mutated H-Ras is a rarer finding that is present in some bladder, breast, and thyroid carcinomas [25]. The gene discussed is HRAS; the disease is colon carcinoma.