Several studies reported nontraditional risk factors such as ancestry, certain single-nucleotide polymorphisms, SLE per se, polyautoimmunity, autoantibodies (i.e., antiphospholipid), markers of systemic inflammation (i.e., CRP), SLE disease activity, SLE duration, organ damage, immune cells aberrations, medication (i.e., glucocorticoids), vasculopathy, lupus nephritis, endogenous dyslipidemia, bone mineral density, education level, and monthly income. The gene discussed is CRP; the disease is lupus nephritis.