Even when overexpression of SF/HGF and/or c-Met promotes glioma growth and angiogenesis in vivo [91], targeting of SF/HGF with single monoclonal antibodies was found to be ineffective, and they were only effective when three antibodies were combined, suggesting that single antibodies against SF/HGF could not fully block the SF/HGF:c-Met binding [92]. Here, HGF is linked to central nervous system cancer.