Similar, in cervical cancer, no protein expression data were presented for most of the KLKs, except for KLK7 and 8 which are up regulated compared to normal cervix tissue.55,56 It is worth mentioning that KLK7 protein content increases with the severity of cervical lesions, i.e. from cervicitis to low-grade cervical intraepithelial neoplasia, high-grade cervical intraepithelial neoplasia, squamous cervical carcinomas, and even cervical adenocarcinomas.57 Obviously, KLK7 could evolve as a useful marker additional to the PAP smear for screening of cervical precursor lesions.57 This evidence concerns the gene KLK7 and cervical intraepithelial neoplasia.