H19 and the insulin-like growing factor 2 (IGF2) are imprinted, and expressed from the maternal allele, and from parental allele, respectively.62,68 The loss of imprinting results in misexpression of H19 and was observed in many tumors including hepatocellular and bladder cancer.64c-MYC induces the expression of H19 in different cell types where H19 potentiates tumorigenesis.68 This evidence concerns the gene H19 and urinary bladder cancer.