In contrast, tissue-specific and Cre-inducible EpA960 transgenic mice, which express the DMPK 3′ UTR with an interrupted CTG960 repeat at relatively high levels, display severe cardiac arrhythmias, muscle wasting and splicing defects (Orengo et al, 2008; Wang et al, 2007). The gene discussed is DMPK; the disease is chronic obstructive pulmonary disease.