Enhanced mis-splicing also occurred for Ryr2, which regulates calcium release from the sarcoplasmic reticulum and RYR2 mutations cause catecholaminergic polymorphic ventricular tachycardia (Venetucci et al, 2012), and Cacna1s, which was recently shown to be mis-spliced in cardiac and skeletal muscle leading to aberrant gating of this Ca(V)1.1 calcium channel (Tang et al, 2012). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.