NTN1 and neoplasm: Proof-of concept studies, in vitro and in mice or chicken models, have shown that the silencing of netrin-1 by netrin-1 siRNA or interference with netrin-1–receptors interaction are associated with tumour cell death and with the inhibition of tumour growth and metastases (Delloye-Bourgeois et al, 2009a; Delloye-Bourgeois et al, 2009b; Dumartin et al, 2010; Fitamant et al, 2008; Paradisi et al, 2009).