Interestingly, netrin-1 has been shown to be upregulated in a sizeable fraction of metastatic breast, lung, ovary and pancreatic cancer, in inflammatory-associated-colorectal cancer and in neuroblastoma (Delloye-Bourgeois et al, 2009a; Delloye-Bourgeois et al, 2009b; Dumartin et al, 2010; Fitamant et al, 2008; Papanastasiou et al, 2011; Paradisi et al, 2009). This evidence concerns the gene NTN1 and colorectal cancer.