Similarly, in pancreatic cancer cell line MiaPacA, where 5FU and Doxorubicin have been shown to upregulate netrin-1 and its receptors, co-treatment of 5FU or Doxorubicin and TRAP-netrinUNC5A potentiated cell death (Fig 4EF). The gene discussed is NTN1; the disease is familial pancreatic carcinoma.