To investigate whether upregulation of netrin-1 and its receptors is restricted to Doxorubicin or is a general response to chemotherapeutic agents, netrin-1 levels were analysed by quantitative RT-PCR in a panel of 15 cancer cell lines in response to various conventional chemotherapeutic drugs, such as Doxorubicin, 5-Fluoruracil (5FU), paclitaxel (Taxol) and Cisplatin. Here, NTN1 is linked to cancer.