Indeed, high-level amplification of the EGFR locus represents the single most common genomic abnormality in GBM, occurring in ~45 % of all cases, and PDGFRA and MET are also frequently amplified, in 10–15 % and ~4 % of GBMs, respectively [5, 10, 31, 43]. The gene discussed is PDGFRA; the disease is glioblastoma.