Our findings also substantiate the role of this gene in various epilepsy syndromes, as is seen also with other epilepsy-related genes such as SCN1A, KCNQ2, and PRRT2. Moreover, our findings lend support to the idea of pleiotropy in epilepsy genetics because, although some mutations in TBC1D24 can cause mild epilepsy without other substantial associated features, other mutations in TCB1C24 cause epilepsy as part of a syndrome with features beyond the nervous system. Here, TBC1D24 is linked to epilepsy.