KCNJ2 and Familial short QT syndrome: Although the mechanism for VF/VT initiated by long-coupled extrasystoles remains speculative, the arrhythmogenic mechanism for VF/VT elicited by short-coupled beats may be explained by the results of the in silico characterization of a KCNJ2 gain-of-function mutation identified in one of our SQTS patients with an extremely short QT interval (14).