CD4 and Increased total eosinophil count: This induces a pronounced eosinophilia and the recruitment of Th2 cells (CD4+IL-4+ and CD4+IL-13+ lymphocytes) to the airway.33,34 Although NK cells are present at low numbers in the airways and lung tissue in homeostasis, we found that they are greatly increased in number in allergic inflammation and that their increase in numbers in the airways over the course of induction of allergic inflammation paralleled development allergic inflammation (Fig E1 [in this article’s Online Repository at www.jacionline.org] and NKp46+CD3− lymphocytes [Fig 1, E]).