Previously, the combined use of TNF blockade with other anti-inflammatory biological agents (for example, combination of etanercept with anakinra) was found to be associated with increased safety risks in humans, including serious infections (0% for etanercept alone, 3.7 to 7.4% for etanercept plus anakinra), injection site reactions and neutropenia [28]. This evidence concerns the gene TNF and Decreased total neutrophil count.