Interestingly, while aspirin is recommended for the management or prevention of numerous thrombotic-associated diseases, such as acute myocardial infarction, acute ischemia/reperfusion injury and unstable angina [60], aspirin has been shown to have little or no effect on the surface expression and subsequent release of CD40L from platelets [61,62]. This evidence concerns the gene CD40LG and myocardial infarction.