A cross-sectional study of elderly women without dementia (11 MDD, 3 dysthymia, 70 non-depressed controls) found an elevated mean CSF-to-serum albumin ratio among those with MDD or dysthymia relative to non-depressed controls (7.1 × 10-3 vs 5.4 × 10-3, age-adjusted P < 0.015) [186]. This evidence concerns the gene ALB and dysthymic disorder.