TGM3 and neoplasm: In univariate and multivariate Cox proportional analyses (Table 1), TGM3 expression status (hazard ratio, 0.286; 95% CI, 0.103-0.796; P = 0.016), together with pathological differentiation of the tumor (hazard ratio, 1.737; 95% CI, 1.042-2.895; P = 0.034), was identified as an independent predictor of clinical outcome in patients with HNSCCs.