This result was consistent with the findings of Uemura, who reported that the 5-year disease-specific survival rate was 64.5% and 32.1%, respectively, for patients with TGM3-positive and TGM3-negative ESCC, and TGM3 was identified as independent predictor in patients with ESCC[18]. This evidence concerns the gene TGM3 and esophageal squamous cell carcinoma.