NR3C1 and post-traumatic stress disorder: Following chronic or traumatic stress, inappropriate adaptation of the HPA axis can lead to pathological states; specifically, changes in glucocorticoid receptors (GRs) have been implicated in the pathogenesis of stress related psychiatric disorders such as post-traumatic stress disorder (PTSD)[6] and symptoms of PTSD are believed to reflect trauma-induced changes that lead to long-term dysfunctional stress regulation[7-9].