To try to overcome this difficulty, some researchers are testing other possibilities to generate cancer-derived hiPSCs by the application of other factors in addition to the Yamanaka factors, such as exogenous expression of miRNA302 and chemical compounds, as azacitidine (DNA methyltransferase inhibitor) and knockdown of p53, p21, and Ink4/Arf [19, 62]. This evidence concerns the gene CDKN2A and cancer.