We divided 15 chromosomal aberrations into three groups: AML, AML1-ETO, PML-RARA and its variant rearrangements (PLZF-RARA, NPM1-RARA), CBFB-MYH11, and MLL rearrangements (MLL-AF9, MLL-ENL, MLL-ELL, MLL-AF6, and MLL-AF10); ALL, MLL-AF4, TEL-AML1, E2A-PBX1, BCR-ABL p190, and SIL-TAL1; CML, BCR-ABL p210 and p230. The gene discussed is AFF1; the disease is acute myeloid leukemia.