Among these sites, the PAS site is gaining more interest in designing novel drugs as the site is involved in catalytic site allosteric modulation and also has importance in noncholinergic functions like cell adhesion, neurite outgrowth in developing and transformed neural cells [28–31] and amyloidosis through an interaction with the amyloid β-peptide in AD [32, 33], and it also has been shown to interact with an omega loop on an adjacent AChE subunit [34]. The gene discussed is ACHE; the disease is Alzheimer disease.