Univariate analysis showed that besides a history of cardiovascular disease (CVDpos, HR 8.1, P < 0.001), age (HR 1.04, P = 0.02), dyslipidaemia (HR 8.8, P = 0.004), and the % of CD4+CD28null T cells (HR 1.04 per % increase, 95% CI 1.00–1.09, P = 0.01) were significantly associated with the occurrence of a posttransplantation AVE. The gene discussed is CD4; the disease is inherited lipid metabolism disorder.