Interestingly, when mo-DCs were generated under the engagement of the tolerogenic receptor PSGL-1 (by the addition of exogenous P-selectin), a diminished capability to promote the generation of Treg lymphocytes was observed in patients with RA and SLE (P < 0.05 compared to controls, in both cases, Figure 5). Here, SELPLG is linked to systemic lupus erythematosus.