Indeed, others have shown that acute severe asthma exacerbations result in a transient decrease in serum adiponectin concentrations [70], similar to the reductions observed in mice challenged with allergen [46], whereas bronchoprovocation from experimental inhalational allergen challenge does not acutely affect serum adiponectin concentrations [75], perhaps because the bronchoconstriction is so transient. The gene discussed is ADIPOQ; the disease is asthma.