Finally, with the use of linear regression analysis, including all children and adolescents, and a priori adjusting for age, gender, and the presence of T1DM, serum levels of OPG were significantly negatively associated with BMI (β −0.335, P-value 0.003), while cIMT measurements were positively associated with BMI (β 0.418, P-value 0.027); serum levels of OPG were a priori included as a confounder for cIMT. The gene discussed is TNFRSF11B; the disease is type 1 diabetes mellitus.