Our study is consistent with contemporary data, particularly in the era of PSA and routine 12 core biopsies [13–17], associating Gleason score discordance with adverse pathological features (advanced tumor stage, more positive points in surgical specimen, extraprostatic extension, positive surgical margins, seminal vesicle invasion, and lower rates of “insignificant” tumors) and worse DFS. This evidence concerns the gene KLK3 and neoplasm.