Ciolino et al. reported that galangin (3,5,7-trihydroxyflavone) caused an increase in the amount of CYP1A1 mRNA, but inhibited the induction of CYP1A1 mRNA by DMBA or by TCDD in MCF-7 human breast cancer cells. The gene discussed is CYP1A1; the disease is breast carcinoma.